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If you're talking about front-end web development, strong fundamentals of HTML5, CSS3, JavaScript are a must, before moving on to any framework.
For backend, strong fundamentals in any programming language (Python/Java/JavaScript/Ruby/Go, etc) is a must, before moving on to the web framework.
If you pick Javascript as your backend language. the advantage is that you don't have to learn 2 different languages for frontend and backend.